Wednesday, March 27, 2013

AIA crowdfunds a space program ad that would run in front of Star Trek (video)

Aerospace industry wants a NASA ad in front of Star Trek, prefers real space travel video

As a federal agency, NASA can't run commercials -- a problem both for rallying broader public support and fostering the next generation of astronauts. The Aerospace Industries Association has both cultural and very practical reasons for improving that public awareness, so it's taking the unusual step of crowdfunding an ad purchase to get the American space program in front of as many eyes as possible. The project would cut a 30-second version of NASA's We Are the Explorers promo (after the break), minus the administration's official endorsement, and run it in at least 50 major movie theaters for eight weeks following the launch of Star Trek Into Darkness on May 17th. The crowdfunding is ostensibly to demonstrate our collective love of space, and would directly translate any money raised beyond the $33,000 goal into ads for more theaters. A cynical industry move? Maybe -- but we won't build starships without a public that's interested in seeing them beyond movie screens, which makes the ad a noble enough cause in our minds.

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Monday, March 25, 2013

AP sources: SD Sen. Johnson won't seek re-election

FILE - In this Oct. 14, 2009 file photo, Sen. Tim Johnson, D-S.D., is seen on Capitol Hill in Washington. Democratic officials say Johnson intends to announce his retirement on Tuesday, March 26, 2013, a decision that gives Republicans a prime opportunity to pick up a seat in 2014. (AP Photo/Haraz N. Ghanbari, File)

FILE - In this Oct. 14, 2009 file photo, Sen. Tim Johnson, D-S.D., is seen on Capitol Hill in Washington. Democratic officials say Johnson intends to announce his retirement on Tuesday, March 26, 2013, a decision that gives Republicans a prime opportunity to pick up a seat in 2014. (AP Photo/Haraz N. Ghanbari, File)

(AP) ? Democratic U.S. Sen. Tim Johnson of South Dakota plans to retire at the end of his term, Democratic officials said Monday ? a departure that gives Republicans a prime opportunity to pick up a seat as they attempt to win back control of the chamber in 2014.

Johnson, the chairman of the Senate Banking Committee, suffered a brain hemorrhage in 2006 and later returned to the Senate and won re-election in 2008 while sometimes using a motorized scooter.

The officials who described Johnson's plans spoke to The Associated Press on condition of anonymity, saying they were not authorized to pre-empt a formal announcement expected Tuesday in South Dakota.

Johnson, 66, is the fifth Democrat to decide to step aside at the end of the term in 2014, joining Carl Levin of Michigan, Tom Harkin of Iowa, Jay Rockefeller of West Virginia and Frank Lautenberg of New Jersey. Two Republicans also have said they plan to retire, and the GOP must gain six seats to win a majority.

Of the five states, South Dakota is seen as the most favorable to Republicans, who control the state's Legislature, governorship and other federal offices. Johnson was seen as competitive, despite the state's GOP tilt, in part because of his reserved manner and independent streak, as well as his committee chairmanship, which gives Johnson Senate clout as well as a robust fundraising base.

Still, Democrats rejected the notion that Johnson's retirement opens the door for a GOP senator. In last November's election, some Republican Senate candidates who appeared to be the heavy favorites ended up losing to Democratic rivals ? including Rick Berg, who lost to Heidi Heitkamp in neighboring North Dakota.

South Dakota Democratic Chairman Ben Nesselhuf noted Democrats' successes over the past 30 years, including former Senate Democratic Leader Tom Daschle.

"I reject the idea that somehow the Republicans has a lock on this state," Nesselhuf said. "By no means is this an impossible task, or even improbable."

Republican Mike Rounds, a popular former two-term governor, has announced his candidacy for the seat, and has been campaigning since last year. Rounds declined to comment on Johnson's retirement.

Attempts by The Associated Press to reach Johnson through his top Senate staff were unsuccessful. Johnson aides would not confirm the retirement but said the senator would hold a news conference on his political future at University of South Dakota in Vermillion Tuesday afternoon.

Aware that Johnson might decide to retire, Democrats in South Dakota and nationally have discussed possible successors on the ticket, including Johnson's son Brendan, South Dakota's U.S. attorney. The younger Johnson Monday said in an interview that he was unaware of his father's decision and declined to discuss whether he would seek the office.

Former U.S. Rep. Stephanie Herseth Sandlin, a contemporary of Brendan Johnson and another heir to a South Dakota Democratic legacy, also is looking at running. A granddaughter of former South Dakota Gov. Ralph Herseth, Herseth Sandlin served six years in the U.S. House before being defeated for re-election in 2010.

Action within Johnson's party is expected quickly. An open Senate seat is rare in South Dakota, and Republicans have gained an upper hand in the state, controlling the governorship, the Legislature, its other Senate seat and its lone U.S. House seat.

Brendan Johnson, appointed U.S. attorney in 2009, has never held elected office and faced questions about his father's involvement in the confirmation process. Assets for the younger Johnson include his father's advisers and donor base.

Herseth Sandlin also has an in-tact network and following in South Dakota, but she could face some problems in a potential primary with Johnson. She opposed to the 2010 Affordable Care Act, a position that is out of step with a majority of party loyalists.

Republican Mike Rounds, a popular former two-term governor, has announced his candidacy for the seat, and has been campaigning since last year.

___

Espo reported from Washington.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-03-25-Senate%20Retirement/id-21d2a73c4b564ff0ac58a60d906a304c

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Kerry in Afghanistan to prod Karzai on future ties

Secretary of State John Kerry walks to a meeting with Afghan President Hamid Karzai at the Presidential Palace in Kabul, Monday, March 25, 2013. Kerry embarked on talks Monday with Karzai amid concerns Karzai may be jeopardizing progress in the war against extremism with his anti-American rhetoric. The session came shortly after the U.S. military ceded control of its last detention facility in Afghanistan, ending a longstanding irritant in relations. (AP Photo/Jason Reed, Pool)

Secretary of State John Kerry walks to a meeting with Afghan President Hamid Karzai at the Presidential Palace in Kabul, Monday, March 25, 2013. Kerry embarked on talks Monday with Karzai amid concerns Karzai may be jeopardizing progress in the war against extremism with his anti-American rhetoric. The session came shortly after the U.S. military ceded control of its last detention facility in Afghanistan, ending a longstanding irritant in relations. (AP Photo/Jason Reed, Pool)

Secretary of State John Kerry meets with Afghan President Hamid Karzai at the Presidential Palace in Kabul, Monday, March 25, 2013. Kerry embarked on talks Monday with Karzai amid concerns Karzai may be jeopardizing progress in the war against extremism with his anti-American rhetoric. The session came shortly after the U.S. military ceded control of its last detention facility in Afghanistan, ending a longstanding irritant in relations. (AP Photo/Jason Reed, Pool)

Afghan President Hamid Karzai walks in the grounds of the Presidential Palace in Kabul, Monday, March 25, 2013, before the arrival of Secretary of State John Kerry. Kerry embarked on talks Monday with Karzai amid concerns Karzai may be jeopardizing progress in the war against extremism with his anti-American rhetoric. The session came shortly after the U.S. military ceded control of its last detention facility in Afghanistan, ending a longstanding irritant in relations. (AP Photo/Jason Reed, Pool)

(AP) ? U.S. Secretary of State John Kerry embarked on talks Monday with Afghan President Hamid Karzai amid concerns Karzai may be jeopardizing progress in the war against extremism with his anti-American rhetoric. The session came shortly after the U.S. military ceded control of its last detention facility in Afghanistan, ending a longstanding irritant in relations.

During Kerry's 24-hour visit to the country ? his sixth since President Barack Obama became president but his first as Obama's secretary of State ? Kerry planned to meet with Karzai, civic leaders and others to discuss continued U.S. assistance to the country and how to wean it from such aid as the international military operation winds down, and upcoming national elections.

Karzai has infuriated U.S. officials by accusing Washington of colluding with Taliban insurgents to keep Afghanistan weak even as the Obama administration presses ahead with plans to hand off security responsibility to Afghan forces and end NATO's combat mission by the end of next year.

U.S. officials accompanying Kerry said he did not plan to lecture Karzai or dwell on the apparent animosity but would make clear once again that the U.S. did not take such allegations lightly, They said he would press Karzai on the need for the April 2014 elections to meet international standards and continue to stress the importance of Afghan reconciliation and U.S. support for a Taliban office in Qatar where talks could occur.

Karzai is expected to travel to Qatar within the week and some movement on the opening of an office is likely then.

Kerry, who arrived in Kabul from Amman, Jordan, had hoped also to travel to Pakistan on his trip to the region but put it off due to elections there. Instead, he met late Sunday in Amman with Pakistani army chief for Gen. Ashfaq Parvez Kayani, officials said.

The pair had a private dinner at the residence of the U.S. ambassador to Jordan as Pakistan continued to seethe in the aftermath of the return from exile to the country of former president Pervez Musharraf, himself a former army chief.

Earlier Monday, the U.S. military ceded control of the Parwan last detention facility near the U.S.-run Bagram military base north of Kabul, a year after the two sides initially agreed on the transfer. Karzai demanded control of Parwan as a matter of national sovereignty.

The top U.S. commander in Afghanistan, Gen. Joseph Dunford, handed over Parwan at a ceremony there after signing an agreement with Afghan Defense Minister Bismullah Khan Mohammadi. "This ceremony highlights an increasingly confident, capable and sovereign Afghanistan," Dunford said.

The dispute over the center threw a pall over the ongoing negotiations for a bilateral security agreement that would govern the presence of U.S. forces in Afghanistan after 2014.

An initial agreement to hand over Parwan was signed a year ago, but efforts to follow through on it constantly stumbled over American concerns that the Afghan government would release prisoners that it considered dangerous.

They have reason to worry. Zakir Qayyum ? a former Guantanamo detainee, was released into Afghan custody in 2007. He was freed four months later and rejoined the Taliban. He has reportedly risen to become the No. 2 in the Taliban.

A key hurdle was a ruling by an Afghan judicial panel holding that administrative detention, the practice of holding someone without formal charges, violated the country's laws. The U.S. argued that international law allowed administrative detentions and also argued that it could not risk the passage of some high-value detainees to the notoriously corrupt Afghan court system.

An initial deadline for the full handover passed last September and another earlier this month.

The detention center houses about 3,000 prisoners and the majority are already under Afghan control. The United States had not handed over about 100, and some of those under American authority do not have the right to a trial because the U.S. considers them part of an ongoing conflict.

There are also about three dozen non-Afghan detainees, including Pakistanis and other nationals that will remain in American hands. The exact number and nationality of those detainees has never been made public.

A new agreement, or memorandum of understanding, was signed at the ceremony by Dunford and Khan, but the U.S. military said it will not be made public. The agreement supplants one signed last March, which had been made public.

The U.S. military said in a statement that the new agreement "affirms their mutual commitment to the lawful and humane treatment of detainees and their intention to protect the people of Afghanistan and coalition forces," an apparent reference to the release of detainees deemed to be dangerous.

There are about 100,000 coalition troops in Afghanistan, including about 66,000 from the United States. American officials have made no final decision on how many troops might remain in Afghanistan after 2014, although they have said as many as many as 12,000 U.S. and coalition forces could remain.

The U.S. started to hold detainees at Bagram Air Field in early 2002. For several years, prisoners were kept at a former Soviet aircraft machine plant converted into a lockup.

In 2009, the U.S. opened a new detention facility next door. The number of detainees incarcerated at that prison, renamed the Parwan Detention Facility, went from about 1,100 in September 2010 to more than 3,000.

After Monday's handover, it was renamed the Afghan National Detention Facility at Parwan and the U.S. military said it would provide the Afghan army with advisers and $39 million in funding.

The United States has spent about a quarter of a billion dollars to build the Bagram facility along with Kabul's main prison located in the capital.

_____

Patrick Quinn in Kabul and Rahim Faiez in Bagram, Afghanistan contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-03-25-AS-Afghanistan-Kerry/id-fde07ea6a25040c0ba611ddafd1bea98

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'A dream team in the making'?

RavensReuters

The NFL wisely dumped the bad news on the first Friday of the NCAA basketball tournament:? The Ravens won?t host the midweek regular-season opener at home.

It?ll be the first time the Super Bowl champion hasn?t opened the season on a Thursday (or Wednesday) at home since 2004, when the Patriots welcomed the Colts following New England?s second NFL title.

The Orioles, who face the White Sox in Baltimore on the same night the Ravens would have christened the 2013 season, opted not to bend.? The NFL opted not to play on Wednesday night, in deference to Rosh Hashanah.? (Here?s hoping the NFL makes that same decision the next time Christmas Eve or Christmas Day fall on a weekend.)? And, as Peter King of SI.com points out in his Monday Morning Quarterback column, an Orioles conflict would have arisen if the Ravens had opened on Sunday night or Monday night of Week One.

So the Ravens will open on the road ? guaranteeing low attendance and even lower TV viewership of the Orioles game that night.? (That?s OK; they?re used to it.)? The Ravens, we?re told, are bracing for a Thursday night opener at Denver, Pittsburgh, or Chicago.

While the Ravens will have to play at each of those places eventually during the coming football campaign, the NFL is about tradition and one of the newest traditions has given the Super Bowl champs a chance to play the first game of the season at home, where all of them (except the 2012 Giants) started 1-0.

But part of the benefit, as King explains it, comes from the mini-bye that follows starting the season on a Thursday, roughly two weeks removed from the preseason dress rehearsal.? The Ravens coaches, per King, ?clearly wanted? a Thursday road game instead of a home game on Sunday or Monday.

King suggests another possibility:? Put the Ravens on the road for the first Thursday of the season, and then give them a Thursday night opener in Week Two.

The only problem with that potential approach is that the NFL wisely adopted in 2012 a scheduling formula that requires every team to play one ? and only one ? short-week game during the season.? Having the Ravens play on the first Thursday night and then on the first short-week Thursday of the season would throw that system out of whack.

Regardless, the ultimate reality show has now given us something else to discuss, debate, and anticipate.? When the 2013 schedule is released, we?ll find out where the Ravens will open the season.

Baltimore at Denver would be the most intriguing.? Unless, of course, the NFL plans the latest installment of the Manning Bowl for the first Sunday night of the season.

And while sending the Ravens to Pittsburgh for the first week of the season seems particularly unfair to the defending champs, we?re told that the Ravens are expecting to play at Heinz Field in prime time at some point this year.? Why not get it out of the way early?

Source: http://profootballtalk.nbcsports.com/2013/03/24/arthur-jones-thinks-the-ravens-are-a-dream-team-in-the-making/related/

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More heartache for Myles Neuts' family | Local | News | The London ...

CHATHAM?-?

The family of Myles Neuts was shocked to discover medical officials disposed of his organs before the family had a chance to claim them.

In 1998, 10-year-old Neuts was found hanging from a coat hook in a washroom stall door at St. Agnes Catholic School in Chatham. The Grade 5 pupil died six days later, after being taken off of life support, and a coroner?s inquest was held into the death,

His parents, Mike and Brenda Neuts, recently saw a newspaper notice from the Ontario Forensic Pathology Service saying it?s reaching out to families to return organs of family members whose deaths involved a coroner?s investigation and autopsy before June 14, 2010.

Mike Neuts knew Myles? pituitary gland had been removed during the autopsy, but when he asked for more information he was shocked to learn his son?s brain and spinal cord had also been removed.

Those details were in an autopsy report and transcripts from the inquest, but Neuts said he overlooked them because he was still distraught.

Neuts also found out the hospital that performed the autopsy had already disposed of his son?s organs.

Dr. Michael Pollanen, chief forensic pathologist for Ontario, said practices in forensic pathology have changed

and organs no longer need to be kept as often,

He said medical ethics about sharing potentially-distressing news with families has also changed over the years.

?The ethical imperatives now have changed to full disclosure, as opposed to non-disclosure.? Pollanen said,

Neuts said he favours full disclosure, but personally contacting families would have been the better route to go, if organs were available.

?I wonder how many people like me have applied and there?s nothing there for us to get out, especially some of us who didn?t know (organs) were gone,? he said.

Pollanen said more than 2,000 individuals have contacted his office about the issue.

Pollanen said there is now a two-year time limit on retaining organs, which wasn?t the case in the past.

Neuts has been critical of the coroner?s inquest process over the years, but said the efforts of Pollanen give him hope that real changes are happening.

?When I got past my raw emotion and took a look at it . . . I need to be fair and say, ?You know what, they?re trying to clean it up and that?s why this happened,?? he said.

--- --- ---

MORE INFORMATION

? To obtain the organs of a family member whose death involved a coroner?s investigation and autopsy, call 1-855-564-4122 or go online to Ontario.ca/OrganRetention.

? Affected families can request organs be sent to a funeral home for cremation or burial and expenses will be covered by the province.

Source: http://www.lfpress.com/2013/03/24/more-heartache-for-myles-neuts-family

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The Union Minister for Communications and Information Technology, Shri Kapil Sibal launching e-Pass Services in HP and Tripura through video links, at a function, in New Delhi on March 25, 2013.

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Genetic analysis saves major apple-producing region of Washington state

Mar. 22, 2013 ? In August 2011, researchers from the U.S. Department of Agriculture were presented with a serious, and potentially very costly, puzzle in Kennewick, Wash. Since Kennewick lies within a region near the heart of Washington state's $1.5 billion apple-growing region, an annual survey of fruit trees is performed by the Washington State Department of Agriculture (WSDA) to look for any invading insects. This time the surveyors discovered a crabapple tree that had been infested by a fruit fly that they couldn't identify.

It was possible that the fly's larvae, eating away inside the crabapples as they grew toward adulthood, belonged to a relatively harmless species that had simply expanded its traditional diet. In that case, they posed little threat to the surrounding apple orchards in central Washington.

But the real fear was that they represented an expansion in the range of the invasive apple maggot fly, known to biologists as Rhagoletis pomonella. If so, then this would trigger a costly quarantine process affecting three counties in the state.

"In one of the world's leading apple-growing regions, a great deal of produce and economic livelihood rested on quickly and accurately figuring out which one of the flies was in that tree," says Jeffrey Feder, professor of biological sciences and a member of the Advanced Diagnostics & Therapeutics initiative (AD&T) at the University of Notre Dame. "And for these flies, it can sometime turn out to be a difficult thing to do."

As Feder and his team, including graduate student Gilbert St. Jean and AD&T research assistant professor Scott Egan, discuss in a new study in the Journal of Economic Entomology, the WSDA sent larvae samples to Wee Yee, research entomologist at the USDA's Yakima Agricultural Research Laboratory in Wapato, Wash. One larva was sent to Notre Dame for genetic analysis. The study sought to compare Notre Dame's genetic analysis to Yee's visual identification after the larvae had developed into adults. Fortunately, the fly identified, Rhagoletis indifferens, is not known to infest apples. The Notre Dame group further demonstrated that it is possible to genetically identify the correct fly species within two days, compared to the four months required to raise and visually identify the fly.

A separate study led by the Feder lab details how the apple maggot fly was recently introduced into the Pacific Northwest region of the U.S., likely via larval-infested apples from the East. The flies have subsequently reached as far north as British Columbia, Canada, and as far south as northern California. So far, though, the apple maggot has not been reported infesting any commercial apple orchards in central Washington.

"The correct identification of the larvae infesting crabapple trees saved the local, state and federal agencies thousands of dollars in monitoring, inspection and control costs," Yee said. "The cost to growers if the apple maggot had been found to be established in the region would have been very substantial (easily over half a million dollars), but the rapid diagnostic test developed at Notre Dame suspended the need to proceed with the rulemaking process, saving staff and administrative costs."

The Feder team is continuing to refine the genetic assays to develop a portable test that would be valuable in apple-growing regions, as well as ports of entry where fruit infested by nonlocal insect species can be rapidly detected, to prevent the spread of the insect.

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The above story is reprinted from materials provided by University of Notre Dame. The original article was written by Kirk Reinbold.

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Transform Your Offline Business To Online | Sharanyan Sharma

Review Overview
Sharanyan SharmaThe exciting news for the small businesses is that the recent E-Commerce revolution has introduced a whole new level playing field offering everyone a fair chance to become an internet business giant very easily enabling everyone to enjoy the big profits.The internet carries the free information flow and everyone?s looking for their necessaries. 8.5110
  • Online Marketing7

  • Offline Marketing10

Total Score8.5

The exciting news for the small businesses is that the recent E-Commerce revolution has introduced a whole new level playing field offering everyone a fair chance to become an internet business giant very easily enabling everyone to enjoy the big profits.The internet carries the free information flow and everyone?s looking for their necessaries.

Hey Guys!

Shopping at the city?center?or running errands around your local town lately? While doing these regular chores, if you look closely, you will find huge changes taken place over the recent years.I?m living in Northern Province Vavuniya City, but No matter where you live, I think the little guys- the small stores, independent business owners are all disappearing. At least in my local town, majority of them can?t be found anymore. Most of the local small families running stores offering the homely personal touch are now being all swallowed up by the latest market dominants, the supermarkets and the chain stores which sell almost anything and everything you may need for the day to day life.

It is a really depressing and pathetic scene where numerous out of town retail parks and supermarkets are uprooting the locals and taking their places. Virtually, each major town or city is basically a carbon copy of one other. Anywhere you travel; there is not much diversity or change you can find anymore. In every city or town, it?s the usual brand of coffee shops, all the same cloth stores, the usual chains of garden care companies, DIY or the same restaurants or electrical outlets.These small businesses owners are struggling to survive a losing battle and are loosing their lifeblood as it is being sucked out.

pic slide1 Local Businesses Becoming Online Giants   Useful Tips

The exciting news for the small businesses is that the recent E-Commerce revolution has introduced a whole new level playing field offering everyone a fair chance to become an internet business giant very easily enabling everyone to enjoy the big profits.The internet carries the free information flow and everyone?s looking for their necessaries.? These are the local folks ? People living in your own area, Your customers with the biggest potentials.

Check out the recent statistics and you?ll get your proof. The trend of researching products and services online is increasing every year as more and more people are getting easy access to high speed internet facilities. Also the smart phone revolution and tablet devices have been a big help. But still, they buy OFFLINE! Grab full advantage of the E-Commerce concept, put your innovative ideas into effect and watch your business flourish. Make this approach, your competitors did and they are doing well.Keep reading and find out how you too can bring out your ?A Game? and someday become an online business giant.

Getting Started Online

Promoting business on the web can be quite overwhelming. This is one of the many reasons why small business owners postpone their advertisement plans over the internet. On the web, there are numerous advertisement techniques available and not having a clear idea might cause trouble deciding where to start from.

Many local businesses dip into the online marketing world and after sometime they give up as the expected results don?t show up.

The internet marketing is efficient and fruitful but it?s not a magic wand which will help you get rich overnight. You know your business by heart, so, now find an easy and simple approach to let the others know.

Not all marketing methods work well for all type of business ventures, but below are some basic things which literally almost any business venture, no matter which sector the venture is related to, can certainly help you to mark your presence on a large scale over the internet without draining your account dry.

Your Online Income Generation Machine ? ?Your Website

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You don?t have to create an expensive website with all singing and dancing works of art. The site should be updated regularly and be search engine friendly.Designing a fully functional and yet profitable website is an extremely daunting task. So, small businesses owners usually leave all the designing and technical works to the hired contractors.This sometimes turns out to be an expensive mistake. Website designers are capable of making stunning looking website designs complete using every bell and whistle.

For example, if you were running a car dealership, you would not trust the car mechanics to run your marketing campaigns. He ?may be a damn good car mechanic, but it is almost unlikely that the mechanic would also be an expert authority on marketing. Hand the control of the marketing campaigns over to him and pretty soon you?ll be out of business.Allowing your website designer to run the website for you would put you into similar situations as mentioned above.

Of course, they come with excellent design skills, but they are not experts on marketing in most cases. Only a few website designers completely understand the effective search engine optimization techniques, or how to present compelling sales information or advertisements which effectively pre-sells the products and services you intend to put on the shelves.Believe me; nobody wants a website designer who only focuses on eye catching designs with pretty looking but absolutely pointless gimmicks providing Zero efficiency.Below some tips are presented that will help you run your website with total control and eventually you?ll be running a website providing a healthy profit.

1.? Think straight and be sure about what it is that you really want. You want and need a website working 24/7 with regular earnings. Be clear about exactly what task each web page is expected to accomplish and design them accordingly. Also, in advance, decide what kind of customers your website is trying to attract.

  1. For example, are you interested in showing off your products via an online brochure or do you want to sell those on the website?
  2. ?Do you want the webpage to collect the visitor?s contact details or just want the site to let the consumers know your contact details?To keep the customers updated you can go for a blog or newsletter delivery.

2.? Place your offers and make the Buy and contact details clearly visible on the website.? People buy online to save time. So, if you want more online buyers, make the Buy button clearly seen. Make sure that your contact details are visible bright and clearly on each web page, so, the customers can call you if needed.

?Download Your Free Ebook ?

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Social media allow you connect with your target audience and have a two-way effective conversation. But it can be easy to forget that not everyone who finds your social media profiles will speak your language, or be able to relate to your region?s latest trends.Social Media Marketing is Secret Weapon for any offline; online business and Brands. Big MNC?s and Small Business owners use social media platform to capture the attention of their target audiences . That?s why?I?ve?created ?special short report about ?Basic E-Commerce Strategies and transform your Business Online using Social media and search Engines. Don?t worry I?m not going to ask you to subscribe my mailing list, but if you like my short report then you can?subscribe my blog to receive Regular updates via email notification.

I hope my short report will help you create some amazing ideas about your business and Brand. Just hit reply to this post and let me know what you thought please.

Talk Soon,

Sharanyan Sharma

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Source: http://www.sharanyan.com/local-business-online-giant/internet-marketing/

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Sunday, March 24, 2013

Marfreless to close (Offthekuff)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories Stories, RSS Feeds and Widgets via Feedzilla.

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Alfonso Ribeiro

Gillmor Gang: It's Alright, Bob | TechCrunch

The Gillmor Gang ? Robert Scoble, Danny Sullivan, Kevin Marks, and Steve Gillmor ? convened with Gillmor in Boston and the Gang in California. We took another cut at the Google Reader damage, with @dannysullivan hating on notifications and @scobleizer hating on Android?s notifications. Did I say I told him so? Yes I did.

But the mere fact we spent so much time on the stream?s destruction of Windows and RSS proved the point all along (for me since 2009). Namely, that the new platform is the stream, and the resulting multiplexed meritocracy of the combined social and messaging networks is where the developers will go. As Dylan said, ?even the President of the United States sometimes must have to stand naked.?

@stevegillmor, @dannysullivan, @scobleizer, @kevinmarks

Produced and directed by Tina Chase Gillmor @tinagillmor

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Widely considered a leading ?search engine guru,? Danny Sullivan has been helping webmasters, marketers and everyday web users understand how search engines work for over a decade. Danny?s expertise about search engines is often sought by the media, and he has been quoted in places like The Wall St. Journal, USA Today, The Los Angeles Times, Forbes, The New Yorker and Newsweek and ABC?s Nightline. Danny began covering search engines in late 1995, when he undertook a study of how they...

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Robert Scoble is an American blogger, technical evangelist, and author. He is best known for his popular blog, Scobleizer, which came to prominence during his tenure as a technical evangelist at Microsoft. Scoble joined Microsoft in 2003, and although he often promoted Microsoft products like Tablet PCs and Windows Vista, he also frequently criticized his own employer and praised its competitors like Apple and Google. Scoble is the author of Naked Conversations, a book on how blogs are changing...

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Kevin Marks is a software engineer. Kevin served as an evangelist for OpenSocial and as a software engineer at Google. In June 2009 he announced his resignation. From September 2003 to January 2007 he was Principal Engineer at Technorati responsible for the spiders that make sense of the web and track millions of blogs daily. He has been inventing and innovating for over 17 years in emerging technologies where people, media and computers meet. Before joining Technorati,...

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Steve Gillmor is a technology commentator, editor, and producer in the enterprise technology space. He is Head of Technical Media Strategy at salesforce.com and a TechCrunch contributing editor. Gillmor previously worked with leading musical artists including Paul Butterfield, David Sanborn, and members of The Band after an early career as a record producer and filmmaker with Columbia Records? Firesign Theatre. As personal computers emerged in video and music production tools, Gillmor started contributing to various publications, most notably Byte Magazine,...

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Source: http://techcrunch.com/2013/03/23/gillmor-gang-its-alright-bob/

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Bodybuilding icon Joe Weider dies in Los Angeles at 93

By Dan Whitcomb

LOS ANGELES (Reuters) - Joe Weider, the self-made fitness and bodybuilding guru who built a magazine empire that included more than a dozen popular publications such as Muscle and Fitness, Shape and Men's Fitness, died on Saturday at the age of 93.

Weider, also known for starting the Mr Olympia bodybuilding contest in the 1960s and mentoring a young Arnold Schwarzenegger, passed away from heart failure at a Los Angeles area hospital, his longtime publicist Charlotte Parker said.

"Joe Weider was a titan in the fitness industry and one of the kindest men I have ever met," Schwarzenegger said in a statement posted on his official website.

"He leaves behind a fantastic legacy of a fitter world," the film star and former governor of California said. "Very few people can claim to have influenced as many lives as Joe did through his magazines, his supplements, his training equipment and his big-hearted personality."

Born in a tough neighborhood of Montreal in 1920, Weider began lifting weights as a teenager to stand up to bullies and older boys before competing in his first bodybuilding contest at the age of 17, according to a biography provided by Parker.

He started his first magazine, Your Physique, in the early 1940s and with his younger brother Ben rented Montreal's Monument National Theater to host the first Mr Canada contest during that same decade.

The two brothers also founded the International Federation of Bodybuilders and in 1965 Weider created the Mr Olympia competition, the sport's premiere bodybuilding contest.

Weider met Schwarzenegger at a bodybuilding contest in Europe and convinced him to move from his native Austria to the United States to seek wider recognition.

"He saw a lot in Arnold," Parker said. "He felt that the sport needed a star and right away he could see that Arnold was something special."

Schwarzenegger, then nicknamed the "Austrian Oak," first gained fame by winning a string of Mr Olympia titles in the early 1970s before going on to a successful career in such films as "The Terminator" and "Total Recall."

He was elected governor of California in 2003 and served two terms before retiring from politics.

"Joe didn't just inspire my earliest dreams; he made them come true the day he invited me to move to America to pursue my bodybuilding career," Schwarzenegger, who visited Weider in the hospital before his death, said in the statement.

"I will never forget his generosity. One of Joe's greatest qualities is that he wasn't just generous with his money; he freely gave of his time and expertise and became a father figure for me," he said.

Schwarzenegger also credited Weider with getting him his first acting role, in a movie called "Hercules in New York," by claiming that the hulking young Austrian was a Shakespearean actor from Germany.

Weider, who also created a line of sports nutritional supplements and ultimately founded more than a dozen fitness magazines including Fit Pregnancy, Living Fit and Flex, sold his Weider Publicans to American Media Inc. in the early 2000s.

He is survived by his wife of more than 50 years, Betty.

(Reporting by Dan Whitcomb; Editing by Colleen Jenkins, David Brunnstrom and Jackie Frank)

Source: http://news.yahoo.com/fitness-bodybuilding-icon-joe-weider-dies-los-angeles-212139218--spt.html

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Apple Buys WifiSlam - Business Insider

Apple has bought indoor GPS company, WifiSlam, reports The Wall Street Journal.

The acquisition cost Apple about $20 million and proves that the iPhone maker is serious about improving its Maps offering, a space that Google currently dominates.

WifiSlam is just two years old, but during that time the start-up has focused on technology that ?can detect a smartphone user's location in a building using Wi-Fi signals," the Journal says.

Before Apple bought WifiSlam the company was offering its technology to app developers for indoor mapping and new types of retail and social networking apps.

Apple's fiercest competitor, Google, already offers indoor mapping in certain locations like airports, shopping centers and sports venues. Users can explore virtually explore these places street-view style.

Here's the official statement Apple gave to the WSJ:

An Apple spokesman confirmed the deal saying the company ?buys smaller technology companies from time to time? and generally doesn?t discuss its plans. He declined to comment further. WifiSLAM could not immediately be reached for comment.

Source: http://www.businessinsider.com/apple-buys-wifislam-2013-3

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Himalayan adventure foretells climate's effects

David Putnam

A hiker treks through Rinchen Zoe plateau in the Bhutanese Himalayas.

By Tanya Lewis
LiveScience

NEW YORK ? The distribution of water in Asia's highest mountains and driest deserts tells an important story of climate change.

Almost half the world's population gets its water from glacier melt and rainfall in the Himalayas and other lofty peaks, yet little is understood about how climate change will affect these water sources. Now, using sophisticated technology and old-fashioned fieldwork, scientists are looking into the past to solve this mystery.

"We're trying to understand the relationships between climate and glaciers and Earth's water resources from the perspective of Earth's paleoclimate," geologist Aaron Putnam of the Lamont Doherty Earth Observatory said in a talk at the Columbic Club in New York on March 12. He described his recent expeditions along the Silk Road, from the Tien Shan Mountains to the Taklamakan Desert to the Bhutanese Himalayas.

Tien Shan Mountains
Putnam and colleagues set out in 2010 to the Tarim Basin in Northwest China, right in the center of Asia. Within the Tien Shan Mountains, a range that extends some 1,740 miles (2,800 kilometers), the scientists studied masses of soil and rock debris built up by glaciers, called moraines, which held clues to the past climate. [Stunning Scenes: From the Himalayas to the Taklamakan Desert]

To determine the ages of the moraines, the researchers used a technique known as beryllium-10 exposure dating. Cosmic radiation constantly bombards the Earth's surface, changing the form of some of the elements, like beryllium, in rocks. Based on these changes, the scientists could determine how long the moraines had been there, which allowed researchers to reconstruct the glaciers' past positions. "We can see what the ice looked like and know exactly when the ice was there," Putnam said.

Deep in the desert
Next, Putnam and colleagues ventured to the Taklamakan Desert. New roads have made the desert accessible, "so we were able to access lands people had died trying to visit even a decade ago," Putnam said. He described the area as a parched, desolate landscape with endless expanses of sand dunes.

As the researchers trekked through the desert, they noticed silts, mud cracks, remnants of trees, even shells ? all telltale signs of water. To find out when this wet period took place, the scientists used radiocarbon dating, a technique that measures the ratio of different forms of carbon to find an object's age. The scientists also used dendrochronology, a method of determining trees' ages based on their growth rings. The results suggested the wet period occurred from the mid-1100s to the late 1800s.

Putnam and his team then traveled to the easternmost part of the desert to an enormous dry lakebed called Lop Nor. They did radiocarbon dating of shells on the lake's shoreline, finding the shells' ages matched those of the other samples from formerly wet areas. That span of time, from the 12th century to the 19th century, was a cold period in North Atlantic regions. "When it got cold in the North Atlantic, it got wet in the midlatitude desert regions," Putnam said.

The onset of wet conditions in the Taklamakan Desert corresponds with the rise of Genghis Khan and the Mongol Empire, the largest contiguous land empire in history. The Mongols relied heavily on horses, which would have needed lots of grass to eat. Putnam and his team think the wetting of the desert allowed grasslands to expand, enabling the Mongols to spread throughout Asia. [10 Surprising Ways Weather Changed History]

Atop the Himalayas
Next, Putnam and his colleagues headed south to the Himalayas of Bhutan, an area swept by the monsoon. "We don't know how the monsoon will affect glacier behavior in the Himalayas," Putnam said, adding, "We just needed to go there and use good old-fashioned fieldwork to figure it out." The team made a six-day trek to their study site, a glacier-laden plateau.

The journey wasn't easy; it took 25 horses and mules to carry all of the supplies from the deep jungles up to the icy peaks. The team hiked over 15,400-foot-high (4,700 meters) mountain passes, home to creatures like the Himalayan blue sheep, or bharal.

Finally, the team crested Bhutan's Rinchen Zoe plateau. They ventured out onto the glaciers and took ice sample to measure the amount of melt. The scientists used the same beryllium dating method as before to determine the age of the glacial deposits, work that is currently in progress. The team had to leave before the snows came with the approaching winter.

Though the scientists haven't finished their analysis yet, it's clear that the glaciers have substantially receded over the last century, Putnam said, and this will have an impact on the many people who depend on the mountains for water.

With the current global warming trend, Putnam expects to see a northward expansion of the deserts. The insights gained on these expeditions were only possible through fieldwork, Putnam said. "In my opinion, there's no substitute for collecting fundamental data from the natural world," he said.

Follow Tanya Lewis @tanyalewis314. Follow us @livescience, Facebook or Google+. Original article on LiveScience.com.

Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://feeds.nbcnews.com/c/35002/f/653377/s/29e15d54/l/0Lscience0Bnbcnews0N0C0Inews0C20A130C0A30C220C174171120Ehimalayan0Eadventure0Eforetells0Eclimates0Eeffects0Dlite/story01.htm

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Obama: Assault weapons ban deserves a vote

President Barack Obama says each of his proposed steps to reduce gun violence should get a vote in Congress ? even an assault weapons ban that both parties agree stands little chance of passing.

Senate Democrats dropped the ban from the bill they plan to debate next month out of concern it could sink the whole package. Still, Obama says he's pushing for it.

In his weekly radio and Internet address released Saturday, Obama says the U.S. has changed in the three months since the December school shooting in Newtown, Conn., left 20 first graders and six educators dead. He says Americans support the ban, plus limits on high-capacity ammunition magazines, school security funding and a crackdown on gun trafficking.

"Today there is still genuine disagreement among well-meaning people about what steps we should take to reduce the epidemic of gun violence in this country. But you, the American people, have spoken," Obama said.

The White House said Saturday that Obama will make additional trips outside Washington to rally support for the measures, including the assault weapons ban. The White House also said that before Obama left for Israel earlier this week, his push for gun control was among the issues he raised with lawmakers from both parties as he embarked on a concerted effort to reach out to Congress.

In the Republican address, Sen. Mike Lee of Utah says the Senate Democrats' budget raises taxes by $1.5 trillion without doing anything to save entitlements like Social Security and Medicare. He says Republicans want a balanced budget that lives up to the nation's moral obligation to act in the best interest of future generations.

"Republicans recognize that keeping dollars, decisions, priorities and power in the hands of the people is what has made America the greatest civilization the world has ever known," Lee says. "Now is the time to return to that model."

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Online:

Obama address: http://www.whitehouse.gov

Republican address: www.youtube.com/gopweeklyaddress

Also Read

Source: http://news.yahoo.com/obama-assault-weapons-ban-deserves-100803110.html

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MPAO2 #15: ??We Are The Past or: Celebrating and Fearing our ...

Many Places At Once Volume 2, Issue #15, ???We Are The Past or: Celebrating and Fearing our Pre-adult Future Overlords?

Students with one of the may robot entries (photo by Josh Beech)

?Children are our future; I made that up, just now.

? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? -Bob Odenkirk

Last Thursday (March 14, 2013), the South West Regional ACTE Fair took place at the Faulkner State Gym and Performing Arts Center in Bay Minette. ?As a student in their computer science program, I was afforded a front row seat as one of the judges. ?It was enlightening, enlivening, and only a little adorable (or maybe just a little bit more than a little bit).

ACTE stands for the Alabama Council for Technology in Education, and while Baldwin County doesn?t at first seem a fitting place from which so many talented and knowledgable children might emerge, there are a few factors that have made these children contenders at the state fair. ?Firstly, Baldwin County?s Digital Renaissance initiative has placed computers ?into the hands and households of every child in the county. ?Secondly, they?re the first generation to have grown up in a time when these devices were an omnipresence in their lives. ?Thirdly, though a far cry from Silicon Valley, the CEO of Apple is an Auburn graduate hailing from Robertsdale.

Once a year, and for the last twenty-nine years, the children of Baldwin County and its seven nearest neighboring counties in the southwestern area of Alabama are gathered to test their skills, ingenuity, and acumen in a number of categories. ?There?s the Literacy Test, a multiple choice exam on an array of topics like computer history, information technology, and networking. ?General Applications is a print-based test of software-assisted displays, such as digital artwork, presentations, digitally altered photographs, etc. ?Multimedia Projects are creative presentations including sound, photographs, video, original artwork? ?Hardware ? Robotics? ?Web Site Creation? Video Production? Computer Programming? ?The best and brightest children from third through twelfth grades gathered to test their hard work, imaginations, and technical prowess, to stunning and impressive results.

Dr. Charles Lake (the guy in the shirt and tie) among the throngs of hungry and hyper students (photo by Josh Beech)

I arrived at 8:30am to join the judges (mostly FSCC students, while the faculty provided Fair administration) and receive my assignment. ?I was paired with a Swedish student named Rebecca, and we were assigned to Level II Group Web Site Creation. ?Level II includes the fifth and sixth graders, which was exactly what I was hoping for. ?A programming student myself, I?m adequate, at best, and therefore was much more interested and qualified to review the work of the younger students out of curiosity about their informational and computer dexterity. ?While the students finished their Literacy tests, we drank coffee, surveyed the gym (which was already set up with rows of tables with spots designated for the numerous schools in attendance), and prepared for the gym to soon be filled to the brim with a humming throng of smarty kids.

So it began. ?We had a larger category, participation-wise, and found ourselves with a great variety of sensibilities, designs, and contents. ?My partner and I were at times underwhelmed (but polite, after all, we were the adults?), delighted, and astonished by the entries.

Two students from Robertsdale Middle School had a website that was simply all about horses; girls just obsessed with fuckin? horses. ?Horse facts, breeds, history, grooming. ?The design was super clean and informative. ?I was somewhat impressed, but the highly impressionable Swede alongside me must have apparently been a horse nut as well, and juked the scoring in their favor so that they ended up winning first place. ?Not my bag, and far from the greatest we saw, in my opinion, but they were sweet and infectious in their excitement for those goddamn horses. ?There were young ladies from St. Ignatius who put together a very savvy (and Lisa Frank-hued) business website to sell their hypothetical cupcakes and clothing. ?After giving us a website tour including a rundown of their products, ?designer? bios, and contact information, they handed us laminated business cards. ?It was irresistibly adorable. ?My favorites were these two boys from St. Ignatius who designed a run-down of their favorite warriors from throughout history: ?Romans, Knights, Ninjas, Spartans, etc. ?They had the statistics and had stacked them against one another on a leaderboard (Spartans were the greatest, obviously). ?Part of their web sources included the Deadliest Warrior wikia, a repository from the Spike TV testosterone-fest. ?On the score sheet, the first category, ??Most Unique? got crossed out and replaced with ?Most Awesome,? and I gave those little dudes a fucking 10.

Two fellow judges (and classmates) finish the final computer programming judgments. (photo by Josh Beech)

After we were finished judging, I was free from my part in the process, so I set about looking over some of the other categories and students. ?The Hardware ? Robotics kids were all pretty killer, making projects ranging from tiny RC forklifts to sensored mice that ran a maze on their own.

The multimedia kids were highly specialized in their interests, with projects ranging from kid-political (ex. ?Uniforms Are Bad And We Shouldn?t Have to Wear Them!?) to grown-up Fox News political (ex. ?Remember 9/11 and God Bless The USA,? a disturbing project once you realize it was created by someone who literally lived in the shadow of that great impasse their entire life).

(photo by Josh Beech)

My programming classmates were busy very harshly judging the high school computer programmers. ?They had some pithy shittalk for the majority of the entries they?d judged, save for one: ?a 15-year-old girl from St. Paul had designed and programmed a Sonic The Hedgehog typing tutorial game that blew their asses up. ?I went and checked it out and was equally impressed; her programming skills were already quite more sophisticated than my own (which isn?t really saying much other than the fact that I?m a college student).

Miss Crabtree (real name) and Mr. Charles ?Don?t Call me Doctor? Hoequist tabulate the final results (photo by Josh Beech)

I went outside during the lunch break and called my wife, who indicated that these kids were the people who I would be competing with for jobs in the next ten years. ?At 9, 12, 18 years old, they were already my competition, though I?d just finished judging them in my capacity as an ?adult.? ?Best not to dwell on that one; I?m not too far from graduation. ?Maybe my personality will win me points in this crowded field. ?Yes, children are our future, indeed, or rather we are their past.

After a lunch of pizzas, hot dogs, hamburgers and sodas, the auditorium building across from the gym was buzzing like a sports arena while the room packed with carbbed up children awaited their judgements. ?The award ceremony was a mad blur of winners presented by teacher and head of the south west fair Dr. Charles Lake, a man best and most diplomatically describe as very fucking active. ?One of the most hyper human beings on the planet, he was a perfect fit for handing out the few hundred awards to deserving and excited children.

By the end of it I was starting to fade; just being around that many highly hyper children at once is exhausting. ?Call it old age, enthusiasm fatigue, or a pizza induced coma, I left after the award ceremony dazed and delighted.

A packed-to-the-gills auditorium of children and teachers waiting for the fair results. (photo by Josh Beech)

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Josh Beech writes hard for the money. ?He also has a his own music review blog and an ongoing summer project over on his twitter page. ?Follow and love him.

?

Source: http://modmobilian.com/2013/03/mpao2-15/

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Central African Republic rebels reach outskirts of capital

By Paul Marin Ngoupana

BANGUI (Reuters) - Rebels in Central Africa Republic reached the outskirts of the capital Bangui on Friday after seizing the nearby town of Damara, rebels and military officials said, a day after the insurgents rejected a peace offer from the president.

A rebel spokesman said they had moved past Damara, some 75 km (50 miles) from Bangui, and had advanced to within 22 kilometers of the riverside capital, which some of their men had already infiltrated.

In Bangui, panicked residents ran through the streets, shops closed and schools sent home pupils after national radio announced the rebel advance.

"Our objective is to take Bangui today," Nelson Ndjadder, spokesman for the CPSK faction of the Seleka rebel coalition, told Reuters by telephone from Paris. "We have 2,000 men on the ground and some have slipped into the capital."

Central Africa Republic has rich deposits of gold, diamonds and uranium but remains one of the least developed countries in the world. A long series of rebellions have crippled the country and conflicts in neighboring Chad, Sudan and Democratic Republic of Congo have also undermined peace efforts.

A regional peacekeeping force from neighboring central African states had established Damara as a 'red line' for the Seleka not to cross when they bore down on the capital last year.

However, residents in Damara said the peacekeepers had simply stood aside to allow the rebels to take Damara on Friday.

"The regional central African forces who were here ran away. Only the Chadians remained and they held talks with the rebels," Bienvenue Yakesse, an inhabitant of Damara, told Reuters by telephone. "The rebels now occupy the whole town."

Seleka resumed hostilities this week, accusing President Francois Bozize of breaking a January peace deal. Bozize, who seized power in a 2003 coup backed by Chad, was outside the country on a visit to South Africa.

France, which is fighting Islamist rebels in northern Mali, has drawn down its troops in Central African Republic from 600 to less than half that number.

A senior official with the regional peacekeeping force said their mandate did not allow them to intervene unless attacked.

"There is not much resistance from the Central African army. Bangui could fall in a couple of hours," said the official, who asked not to be identified.

"EVERYTHING IS CLOSED"

Presidency spokesman Gaston Mackouzangba confirmed the rebels had clashed with Central African Republic troops in Damara but could not provide further details.

"The rebels have crossed the red line to enter Damara," he told Reuters by telephone. "The president has never closed the door to dialogue."

A statement from the South African presidency said Bozize paid President Jacob Zuma a "courtesy call" in Pretoria on Friday but gave no detail on the content of their talks. South Africa has some 400 peacekeepers stationed in Central African Republic.

A government minister, who asked not to be identified, said Bozize had instructed his cabinet to seek safety.

"Everything is closed here," Saint Hardy, an accountant in Bangui, told Reuters by telephone, saying army units were rushing to the city's outskirts to face the rebels. "If they took Damara at midday they will be in Bangui quickly because there are no other towns on the road."

Military officials said the rebels had also captured Bozize's hometown of Bossangoa, some 300 km (190 miles) from Bangui, one of the largest towns in the country's north and a barracks for the republican guard.

"It is serious. Bossangoa has fallen," said one senior Central African Republic defense official. "Our men tried to resist but without success."

(Reporting by Daniel Flynn in Dakar and Ange Aboa in Abidjan; Editing by Bate Felix)

Source: http://news.yahoo.com/central-african-republic-rebels-advance-toward-capital-125103454--finance.html

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When Flying in a Group, Distribute Everyone's Clothing Throughout Each Suitcase So Nobody Loses Everything

When Flying in a Group, Distribute Everyone's Clothing Throughout Each Suitcase So Nobody Loses EverythingWhen one traveler's suitcase gets lost, they lose everything because all their stuff is stored in a single bag. If a group travels and distributes each person's belongings throughout every suitcase, one lost suitcase won't leave anyone with absolutely nothing. Redditor whedonmoffatparadigm explains:

At the very least, make sure each case contains at least one complete outfit for each person. That way, if one of the cases is lost, no one will be completely without a change of clothes. If you're travelling alone and are checking a bag, take a change of clothes in your carry on, for the same reason. At the very least, take a change of underwear in your carry on.

Basically, pack your bags kind of like a RAID 5 or 6 array and you can still recover easily from a loss. This might make packing and unpacking kind of a pain, but it shouldn't be too much of a problem for families.

When flying with your family, spread everyone's clothes out among several suitcases | Reddit

Photo by Kristen Taylor.

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/ttQLS3i9rDY/when-flying-in-a-group-distribute-everyones-clothing-throughout-each-suitcase-so-nobody-loses-everything

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Misregulated genes may have big autism role

Friday, March 22, 2013

A new study finds that two genes individually associated with rare autism-related disorders are also jointly linked to more general forms of autism. The finding suggests a new genetic pathway to investigate in general autism research.

The genes encode the proteins NHE6 and NHE9, which are responsible for biochemical exchanges in the endosomes of cells. Mutations in the NHE6 gene are a direct cause of Christianson Syndrome, while mutations in the NHE9 gene lead to a severe form of autism with epilepsy. In the new study, a statistical analysis published online this week in the journal Molecular Psychiatry, Brown University researchers and their colleagues found a specific pattern of misregulation of those two genes ? NHE9 is up-regulated and NHE6 is down-regulated ? in the brains of children with autism compared to the brains of non-autistic children.

"These genes play a role, not just in the rare forms of autism but also in the generalized pathology of autism," said Dr. Eric Morrow, professor of biology and professor of psychiatry and human behavior at Brown University, the paper's senior author. "In autism I think people get overwhelmed because there are hundreds of different genes. One of the important things is to find points of convergence where there are events that might be common across different forms."

The new study suggests that misregulation of NHE6 and NHE9 is one such event.

The research is based on a statistical analysis of messenger RNA samples from a bank of brain tissue donated posthumously by some children who had autism and some who did not. Messenger RNA is a key molecular player in the process of gene expression, making it an indicator of how gene expression was regulated in the cerebral cortex of each of the children.

Guided by Morrow, who studies autism genomics and sees autism patients at the E.P. Bradley Hospital in East Providence, lead author Matthew Schewede spent the summer of 2012 poring over the raw data, which was made available from a 2011 study led by co-author Daniel Geschwind and Irinia Voineagu of the University of California?Los Angeles.

Schwede, who studied statistics as an undergraduate at Harvard, is now a second-year student in the Warren Alpert Medical School. His classes are a block away from Morrow's lab, making the collaboration easy.

"We kind of stumbled on this," Schwede said. "At first we were just identifying what was up- and down-regulated in autism cerebral cortex in this data set."

But Schwede's findings about the NHE genes caught Morrow's attention in particular, because Morrow has been studying the NHE6 and NHE9 genes and the rare autism forms they cause.

"When we realized that some genes of interest for our lab were altered in the cerebral cortex, we focused the analysis on these genes in particular and how they were related to other processes," Schwede said.

Schwede made a second key finding: a strong and significant correlation between the misregulation of the NHE genes and the down-regulation of synapse genes, which is known to occur in autism.

Schwede's purely statistical analysis does not explain the physiology of how up-regulation of NHE9 and down-regulation NHE6 would affect synapse formation or general autism, but Morrow's biology group has a clear next step: to observe the neural and behavioral effects in the lab of misregulation of those genes in various experimental systems.

"That's a hypothesis that we can take to the mouse," Morrow said. "When we knock out these genes, how do the synapses change?"

The statistical results point out the value of studying rare forms of autism, not only for the sake the patients who have those conditions, Morrow said, but also because doing so can inform research about other forms of autism.

"We argue that it's relevant but sometimes, in fairness, we wonder about that," Morrow said. "A study like this really conveys strongly that that's a fair argument."

###

Brown University: http://www.brown.edu/Administration/News_Bureau

Thanks to Brown University for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127406/Misregulated_genes_may_have_big_autism_role

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